Ceftaroline fosamil

SKU: orb1299865

Description

Ceftaroline fosamil (TAK-599) is a broad-spectrum cephalosporin antibiotic effective against resistant Gram-positive bacteria, including MRSA. It is widely used in microbiological and pharmacological research for both in vitro susceptibility testing and in vivo efficacy studies in animal infection models.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 400827-46-5
• MW: 744.74
• Purity: ≥98% (May vary between batches)
• Formula: C₂₄H₂₅N₈O₁₀PS₄
• SMILES: CCON=C(C1=NSC(=N1)NP(=O)(O)O)C(=O)NC2C3N(C2=O)C(=C(CS3)SC4=NC(=CS4)C5=CC=[N+](C=C5)C)C(=O)O.CC(=O)[O-]
• Target: Antibacterial|||Antibiotic
• Solubility: DMSO:14 mg/mL (18.8 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.69 mM)

Bioactivity

• In Vivo:
  Ceftaroline fosamil 600 mg given every 12 h was superior to ceftriaxone 2 g given every 24 h for the treatment of Asian patients with PORT III-IV community-acquired pneumonia. These data suggest that ceftaroline fosamil should be regarded as an alternative to ceftriaxone in empirical treatment regimens for this patient population.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TAK 599, TAK599, TAK-599, T-91825, PPI 0903, PPI0903, PPI-0903, prodrug, Bacterial, Antibiotic, Ceftaroline fosamil, Inhibitor, MRSA, infection, inhibit, N-phosphono

Compound Identifiers

PubChem CID

76419086