Cefotaxime sodium

SKU: orb1224364

Description

Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis). (In Vitro):Cefotaxime sodium exhibits an MIC of 0.0625 mg/L for V. vulnificus CMCP6.(In Vivo):The combination of ciprofloxacin and cefotaxime is more effective in clearing V. vulnificus in vivo than previously used regimens.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 64485-93-4
• MW: 477.44
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₆N₅NaO₇S₂
• SMILES: CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OC)/C3=CSC(=N3)N)SC1)C(=O)[O-].[Na+]
• Target: Antibacterial
• Solubility: DMSO: 47mg/mL

Bioactivity

• In Vivo:
  The combination of ciprofloxacin and cefotaxime is more effective in clearing V. vulnificus In vivo than previously used regimens. Animal model: Female, specific pathogen free, 8-week-old BALB/c mice. Dosage: 30 mg/kg. Administration: IP every 6 h. Result: The viable bacterial counts in liver were lower in mice treated with cefotaxime-plus-ciprofloxacin than in those treated with cefotaxime alone (P<0.001 at 24 h and 48 h, each).
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• In Vitro:
  Cefotaxime sodium exhibits an MIC of 0.0625 mg/L for V. vulnificus CMCP6.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Antibacterial