Cefmenoxime hydrochloride

SKU: orb1224059

Description

Cefmenoxime hydrochloride is a third-generation cephalosporin antibiotic.(In Vitro):Cefmenoxime (SCE-1365) hydrochloride inhibits at least 90% of strains tested (MIC90) ranged from 0.06 to 8 μg/mL for the Enterobacteriaceae.Cefmenoxime (SCE-1365) hydrochloride inhibits MIC90 values for gram-positive cocci are 0.015 and ≤0.008 μg/mL for Streptococcus pneumoniae and Streptococcus pyogenes, respectively, and 2 μg/mL for S. aureus.Cefmenoxime (SCE-1365) hydrochloride against Haemophilus influenzae, Neisseria gonorrhoeae, and Neisseria meningitidis with MIC90 values ranging from ≤0.008 to 0.25 μg/mL.(In Vivo):Cefmenoxime (SCE-1365) hydrochloride (40 mg/kg; i.h.; daily, for 7 d; male Jcl:ICR mice) improves the survival rate of mice infected with lung bacteria.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 75738-58-8
• MW: 1059.58
• Purity: >98% (HPLC)
• Formula: C₃₂H₃₅ClN₁₈O₁₀S₆
• SMILES: CN1N=NN=C1SCC2=C(N3C(=O)C(C3SC2)NC(=O)/C(=N/OC)/C4=CSC(=N4)N)C(=O)O.CN1N=NN=C1SCC2=C(N3C(=O)C(C3SC2)NC(=O)/C(=N/OC)/C4=CSC(=N4)N)C(=O)O.Cl
• Target: Antibacterial
• Solubility: DMSO: 8 mg/mL

Bioactivity

• In Vivo:
  Cefmenoxime (SCE-1365) hydrochloride (40 mg/kg; i.h.; daily, for 7 d; male Jcl: ICR mice) improves the survival rate of mice infected with lung bacteria. Animal model: Male Jcl: ICR mice. Dosage: 40 mg/kg. Administration: Subcutaneous injection; daily, for 7 days. Result: Inhibited mortality rate of animals was 60% at a dose of 40 mg/kg.
• In Vitro:
  Cefmenoxime (SCE-1365) hydrochloride inhibits at least 90% of strains tested (MIC90) ranged from 0.06 to 8 μg/mL for the Enterobacteriaceae. Cefmenoxime (SCE-1365) hydrochloride inhibits MIC90 values for Gram-positive cocci are 0.015 and ≤0.008 μg/mL for Streptococcus pneumoniae and Streptococcus pyogenes, respectively, and 2 μg/mL for S. aureus. Cefmenoxime (SCE-1365) hydrochloride against Haemophilus influenzae, Neisseria gonorrhoeae, and Neisseria meningitidis with MIC90 values ranging from ≤0.008 to 0.25 μg/mL.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SCE-1365

Quick Database Links

Gene Symbol

Antibacterial