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Cediranib

SKU: orb1225421

Description

A highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively; also inhibits c-Kit and PDGFRβ with IC50 of 2 and 5 nM, >36-fold selectivity over PDGFR-α, >1000-fold over Flt-3 and EGFR; inhibits VEGF-stimulated proliferation and KDR phosphorylation with IC50 of 0.4 and 0.5 nM in human umbilical vein endothelial cells; inhibits angiogenesis, neovascular survival and tumor growth in vivo. Ovarian Cancer Phase 3 Clinical.

Images & Validation

Key Properties

CAS Number288383-20-0
MW450.5053
Purity>98% (HPLC)
FormulaC25H27FN4O3
SMILESCOC1=C(OCCCN2CCCC2)C=C2N=CN=C(OC3=C(F)C4=C(NC(C)=C4)C=C3)C2=C1
TargetVEGFR
SolubilityDMSO: ≥ 49 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AZD2171 | AZD 2171 | AZD-2171

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Cediranib (orb1225421)

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Available Sizes

Select a size below

2 mg
$ 70.00
5 mg
$ 100.00
10 mg
$ 130.00
25 mg
$ 190.00
50 mg
$ 250.00
100 mg
$ 340.00
200 mg
$ 600.00
500 mg
$ 940.00