CDKI-83

• Catalog Number: orb1738193
• Category: Small Molecules
• Description: CDKI-83
• CAS Number: 1189558-88-0
• Purity: 0.98
• MW: 485.58
• SMILES: C(#N)C=1C(=NC(NC2=CC(S(=O)(=O)N3CCOCC3)=C(C)C=C2)=NC1)C=4SC(NC)=NC4C
• Formula: C₂₁H₂₃N₇O₃S₂
• Biological Activity: CDKI-83 is a potent CDK9 inhibitor. The compound shows effective anti-proliferative activity in human tumour cell lines with GI50 < 1 μM, and is capable of inducing apoptosis in A2780 human ovarian cancer cells as determined by the activated caspase-3, Annexin V/PI double staining and accumulated cells at the sub-G1 phase of cellcycle. The research results suggest that combined inhibition of CDK9 and CDK1 may result in the effective induction of apoptosis and CDKI-83 has the potential to be developed as an anti-cancer agent.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.