CDK9/EZH2-IN-1

SKU: orb3027654

Description

CDK9/EZH2-IN-1 is a dual-target inhibitor of CDK9 and EZH2 with IC50 values of 83.9 nM and 108.6 nM, respectively. It induces apoptosis and causes DNA double-strand breaks (DSB). Additionally, CDK9/EZH2-IN-1 inhibits the proliferation of MKN45, MDA-MB-453, and SW620 cancer cells, with respective IC50 values of 136.3 nM, 171.3 nM, and 315.7 nM.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 3081246-18-3
• MW: 906.17
• Formula: C₄₇H₅₉N₁₁O₄S₂
• SMILES: O=C(NCC=1C(=O)NC(=CC1C)C)C2=CC(=CC3=C2C=NN3C(C)C)C=4C=NC(=CC4)N5CCN(CC5)CCN6CCC(C(=O)NC7=NC=C(S7)SCC8=NC=C(O8)C(C)(C)C)CC6
• Target: CDK,Histone Methyltransferase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CDK,Histone Methyltransferase