CDK7-IN-26

SKU: orb3132830

Description

CDK7-IN-26 (compound 36) is an orally active CDK7 inhibitor with an IC50 of 7.4 nM. The compound effectively suppresses the growth of xenograft tumors derived from triple-negative breast cancer (TNBC) cell lines in vivo and has an IC50 of 0.15 μM for inhibiting MDA-MB-453 cells in vitro.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 3024545-79-4
• MW: 468.49
• Formula: C₂₂H₂₂FN₆OPS
• SMILES: N(C1=NC(=C2C(=N1)C=CS2)C=3C=4C(NC3)=C(P(C)(C)=O)C(C#N)=CC4)[C@H]5C[C@H](F)CNC5
• Target: CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CDK