CDK6/9-IN-2

SKU: orb3136364

Description

CDK6/9-IN-2 is a highly potent dual inhibitor of CDK6 (IC50 = 15 nM) and CDK9 (IC50 = 22 nM) with selectivity over CDK2, CDK8, and CDK11. It suppresses proliferation in IFN-γ/TNF-α-induced HaCaT cells and inhibits the STAT3 pathway and expression of inflammatory factors. CDK6/9-IN-2 alleviates psoriasis dermatitis and is applicable in psoriasis research.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3068529-24-5
• MW: 480.01
• Formula: C₂₅H₃₀ClN₇O
• SMILES: O[C@@H]1CN(C2=CC=C(NC3=NC(NC4=CC=C(C=C4)N5CCN(C)CC5)=NC=C3Cl)C=C2)CC1
• Target: STAT,Interleukin,CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

STAT,Interleukin,CDK