CDK5 inhibitor 20-223

SKU: orb1693481

Description

CP668863 (20-223) is a potent, dual CDK2/CDK5 inhibitor with IC50 values of 6.0 nM and 8.8 nM, respectively. It demonstrates anti-colorectal cancer potential in vitro by inhibiting cell migration and inducing cell cycle arrest in multiple CRC cell lines.

Research Area

Cell Biology, Pharmacology & Drug Discovery; Cell Biology

Key Properties

• CAS Number: 865317-30-2
• MW: 305.37
• Formula: C₁₉H₁₉N₃O
• SMILES: O=C(NC1=NNC(=C1)C2CCC2)CC=3C=CC=4C=CC=CC4C3
• Target: CDK
• Solubility: DMSO:80 mg/mL (261.98 mM);10% DMSO+90% Corn Oil:5 mg/mL (16.37 mM)

Bioactivity

• Target IC50:
  CDK2/CDK5:362 nM
• In Vivo:
  In mice, CDK5 inhibitor 20-223 (8 mg/kg, 3 weeks) significantly reduced tumor growth without toxicity and lowered pFAK levels in tumors.
• In Vitro:
  CDK5 inhibitor 20-223 inhibits CDK2/CDK5 (IC₅₀ ≈ 362 nM), causes cell cycle arrest, reduces RB and FAK phosphorylation, and blocks CRC cell migration. CRC cell lines SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CP668863, CP 668863

Compound Identifiers

PubChem CID

69761759