CDK4/6/HDAC-IN-1

SKU: orb2945256

Description

CDK4/6/HDAC-IN-1 (N14) is a potent dual inhibitor of CDK4/6 and HDAC1/6, demonstrating low nanomolar IC50 values. It induces G0/G1 arrest and apoptosis via the HDAC-p21-CDK axis, showing efficacy in inhibiting hepatocellular carcinoma in preclinical research models.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• MW: 665.742
• Formula: C₃₅H₃₉N₉O₅
• SMILES: CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCN(CC4)CC(=O)NC5=CC=C(C=C5)/C=C/C(=O)NO)C6CCCC6)C(=O)C
• Target: CDK,HDAC,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172677061