CDK2-IN-51

SKU: orb3174101

Description

CDK2-IN-51 is a pyrazolopyridine derivative and acts as a CDK2 inhibitor with an IC50 of 23.47 nM. It reduces the expression of DNA replication factors (Polα, MCM7, ORC2, and ORC4) and causes cell cycle arrest before the G1 phase. CDK2-IN-51 does not induce apoptosis and does not significantly affect CDK2 protein expression. This compound is applicable in colorectal cancer research.

Research Area

Cell Biology

Key Properties

• CAS Number: 1443-10-3
• MW: 288.35
• Formula: C₁₈H₁₆N₄
• SMILES: N=1C2=NN3C(N=C(C=C3C)C)=C2C(=CC1C)C=4C=CC=CC4
• Target: CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CDK