Cdk1/2 Inhibitor III

SKU: orb1707478

Description

Cdk1/2 Inhibitor III is a potent and selective small molecule targeting CDK1 and CDK2 kinases, exhibiting an IC50 of 2.1 μM against the CDK1/cyclin B complex. This inhibitor is a valuable research tool for studying cell cycle progression, proliferation, and apoptosis in various in vitro cellular models.

Research Area

Cell Biology, Pharmacology & Drug Discovery; Cell Biology

Key Properties

• CAS Number: 443798-55-8
• MW: 425.44
• Purity: >99.99% (May vary between batches)
• Formula: C₁₅H₁₃F₂N₇O₂S₂
• SMILES: C(NC1=C(F)C=CC=C1F)(=S)N2C(NC3=CC=C(S(N)(=O)=O)C=C3)=NC(N)=N2
• Target: CDK
• Solubility: DMSO:45 mg/mL (105.77 mM)

Bioactivity

• Target IC50:
  CDK2-CyclinA:0.5 nM|CDK1-CyclinB:2.1 μM|CDK1-CyclinB:0.6 nM
• In Vitro:
  Cdk1/2 Inhibitor III exhibits weak CDK1 inhibition and possesses cellular antiproliferative properties.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDK2, Cdk1/cyclin B, CDK1/CyclinB, Cdk1/2 Inhibitor III, Cdk-1/2 Inhibitor III

Compound Identifiers

PubChem CID

5330814