GDC-4198

SKU: orb3135449

Description

GDC-4198 (Compound EX.161) is an orally active, blood-brain barrier-penetrating small-molecule inhibitor that selectively inhibits the cyclin-dependent kinases CDK2, CDK4, and CDK6. GDC-4198 exerts its antiproliferative effects by inhibiting the phosphorylation of retinoblastoma protein (pRb) through the disruption of cyclin-CDK complex activity, thereby interfering with the cell cycle. GDC-4198 shows potential for application in the treatment of tumors such as hormone receptor-positive/HER2-negative breast cancer, lung cancer, and colorectal cancer.

Research Area

Cell Biology

Key Properties

• CAS Number: 2531743-46-9
• MW: 470.57
• Formula: C₂₆H₃₀N₈O
• SMILES: C(C)(C)C1=C2N(C=CC(=C2)C3=NC(NC4=CC=C(C=N4)N5C(=O)C[C@@H](N(C)C)CC5)=NC=C3)N=C1
• Target: CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CDK