CDD-1653

SKU: orb2646229

Description

CDD-1653 is a potent and selective BMPR2 kinase inhibitor (IC50 = 2.8 nM) that blocks ATP binding, thereby suppressing SMAD1/5/8 phosphorylation and BMP signaling. This tool compound is used in research applications, including in vitro and in vivo studies, investigating diseases linked to dysregulated BMP pathways such as pulmonary arterial hypertension and heterotopic ossification.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3034216-44-6
• MW: 454.5
• Formula: C₂₁H₂₂N₆O₄S
• SMILES: O=C1N(C=2C=CC=CC2)CCN(C3=NC(=NC=C3OC)NC4=CC=CC(=C4)S(=O)(=O)N)C1
• Target: TGF-beta/Smad

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

167312383