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CD28-IN-3

SKU: orb3210140

Description

CD28-IN-3 is a CD28 inhibitor with an IC50 of 7.80 μM and a Kd of 52.45 μM. It selectively disrupts the CD28-B7 interaction, thereby inhibiting CD28-mediated costimulatory signaling. CD28-IN-3 enhances the production of pro-inflammatory cytokines IFN-γ, IL-2, and TNF-α. This compound is utilized in research on checkpoint-resistant cancers.

Images & Validation

Key Properties

CAS Number850550-70-8
MW364.53
FormulaC17H24N4OS2
SMILESO=C(NC(C)CC)CSC1=NN=C(S1)NC2=CC=C(C=C2)C(C)C
TargetImmunology/Inflammation related,Interleukin,TNF,IFNAR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information