CD28-IN-1

SKU: orb3173190

Description

CD28-IN-1 (Compound 19MS-5) is a CD28 inhibitor with a dissociation constant (KD) of 12.48 μM. It demonstrates excellent binding affinity to CD28, effectively hindering the CD28-B7 interaction. CD28-IN-1 suppresses CD28-driven immune activation and reduces cytokine production (IFN-γ, IL-2, and TNF-α) in primary human T cells co-cultured with tumor spheroids and human epithelial tissues. This compound is suitable for use in tumor immunology research.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 1465291-19-3
• MW: 315.33
• Formula: C₁₆H₁₇N₃O₄
• SMILES: O=C(OCCC=1C(=NNC1C)C)C2=CC=CC3=C2OC(=O)N3C
• Target: Interleukin,TNF,IFNAR,Immunology/Inflammation related

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Interleukin,TNF,IFNAR,Immunology/Inflammation related