CCTA-1523

SKU: orb1298002

Description

CCTA-1523 is a selective inhibitor of the ABCG2 efflux transporter. It is used in research to reverse multidrug resistance (MDR) in cancer cells, facilitating studies on chemosensitization in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1616271-41-0
• MW: 340.2
• Purity: 99.71% (May vary between batches)
• Formula: C₁₆H₁₅Cl₂NO₃
• SMILES: O(C)C=1C=C(C=CC1OC)C2=CC(NC(C(Cl)Cl)=O)=CC=C2
• Target: ABC Transporter,BCRP
• Solubility: DMSO:50 mg/mL (146.97 mM)

Bioactivity

• In Vivo:
  Co-administration of CCTA-1523 restored the in vivo antitumor activity of doxorubicin in ABCG2 overexpressing tumor xenografts.
• In Vitro:
  CCTA-1523 (5μM) sensitized the ABCG2 overexpressing cancer cells and ABCG2 transfected cells to the substrate chemotherapeutic drugs.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CCTA 1523, CCTA1523, CCTA-1523

Compound Identifiers

PubChem CID

73438576