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CCT400028

SKU: orb3211510

Description

CCT400028 is a PROTACs degrader that targets the Aurora A (AURKA) kinase. It functions by recruiting cereblon (CRBN) E3 ubiquitin ligase, which induces ubiquitination and proteasomal degradation of the target protein. The compound exhibits the following affinity for human Aurora isoforms: KD values of 71 nM for A, 2100 nM for B, and >10000 nM for C, with an IC50 of 6300 nM for human CRBN. CCT400028 is applicable in research related to leukemia, neuroblastoma, and glioma.

Images & Validation

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CCT400028

Key Properties

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TargetAurora Kinase,E1/E2/E3 Enzyme,PROTACs

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Quick Database Links

Gene Symbol
Aurora Kinase,E1/E2/E3 Enzyme,PROTACs

Protocol Information

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