CCT241533 dihydrochloride

SKU: orb1693518

Description

This potent and selective small molecule inhibitor of Chk2 (IC50 = 3 nM) demonstrates over 63-fold selectivity versus Chk1 and 84 other kinases. It effectively blocks Chk2 activation and downstream signaling in cellular models, as shown by its inhibition of etoposide-induced Chk2 activation in HT29 cells and suppression of radiation-induced apoptosis in mouse thymocytes.

Research Area

Cell Biology

Key Properties

• CAS Number: 1962925-28-5
• MW: 515.41
• Formula: C₂₃H₂₉Cl₂FN₄O₄
• SMILES: Cl.Cl.COc1cc2nc(nc(N[C@@H]3CNC[C@H]3C(C)(C)O)c2cc1OC)-c1cc(F)ccc1O
• Target: Others,Chk

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

137025388