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CCP-biotin Peptide (non-cyclized)
Catalog Number: orb1980129
| Catalog Number | orb1980129 |
|---|---|
| Category | Small Molecules |
| Description | CCP-biotin peptide (non-cyclized) is a biotin-labeled linear form of cyclic citrullinated peptide (CCP), designed for the detection of anti-citrullinated protein antibodies (ACPAs), which may recognize its linear structure. This peptide corresponds to amino acids 447-467 of human filaggrin (UniProt ID: P20930) and includes Q447H, S449C, G459R, E460G, and S462C substitutions, with citrullination at arginine 455. |
| Purity | 98.00% |
| MW | 2569.7 kDa |
| Biological Activity | CCP-biotin peptide (non-cyclized) is a linear, biotin-labeled derivative of the circular citrullinated peptide (CCP), mirroring the human filaggrin sequence from amino acids 447 to 467 with specific substitutions (Q447H, S449C, G459R, E460G, and S462C) and a citrullination at arginine 455. This formulation is designed for the identification of anti-citrulline autoantibodies that may recognize and interact with the linear configuration of the peptide. |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
