CCKBR agonist-1

SKU: orb3180491

Description

CCKBRagonist-1 (Compound 3r1) is a selective agonist for the cholecystokinin B receptor (CCKBR) that preferentially activates the Gq protein, with an EC50 of 35 pM. It significantly enhances neuronal survival at an EC50 of 37 pM. CCKBRagonist-1 improves cognitive decline in mice by upregulating α-secretase (ADAM10) and the calcium signaling molecule PLCB4, reduces the number of amyloid β (Aβ) plaques, and promotes long-term potentiation (LTP). This compound is useful for Alzheimer's disease research.

Research Area

Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• Target: Beta Amyloid,MMP,Cholecystokinin Receptor
• CAS Number: 2923120-30-1
• MW: 699.6
• Formula: C₃₂H₃₉BrN₆O₇
• SMILES: C([C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC(Br)=CC=C1)C(N)=O)=O)CC(O)=O)=O)CCCC)=O)NC(C)=O)C=2C=3C(NC2)=CC=CC3

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Beta Amyloid,MMP,Cholecystokinin Receptor