CCG258208 hydrochloride

SKU: orb1694242

Description

GRKs-IN-1 hydrochloride (Compound 14as) is a potent and selective GRK2 inhibitor (IC50=130 nM) derived from paroxetine. It demonstrates a significant, 100-fold improvement over paroxetine in enhancing cardiomyocyte contractility in vitro, making it a valuable research tool for studying heart failure and GPCR signaling pathways.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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MW	488.94
Formula	C₂₄H₂₆ClFN₄O₄
SMILES	FC(C=C1)=C(C(NCC2=CC=NN2)=O)C=C1[C@H]3[C@H](COC4=CC5=C(OCO5)C=C4)CNCC3.Cl
Target	GRK

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

GRK

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