CCG-63808

SKU: orb1308481

Description

CCG-63808 is a reversible, small-molecule inhibitor targeting RGS proteins, specifically demonstrating potent activity against RGS4 with an IC50 of 1.9 μM in TR-FRET binding assays. This compound is a valuable pharmacological tool for investigating G-protein signaling pathways in both cellular and biochemical research contexts.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 620113-73-7
• MW: 454.48
• Purity: 90.00% (May vary between batches)
• Formula: C₂₅H₁₅FN₄O₂S
• SMILES: Cc1cccn2c1nc(Oc1ccc(F)cc1)c(\C=C(/C#N)c1nc3ccccc3s1)c2=O
• Target: GTPase
• Solubility: DMSO:1 mg/mL (2.2 mM)

Bioactivity

• Target IC50:
  RGS4:1.9 μM
• In Vitro:
  CCG-63808 showed selectivity among RGS proteins with a potency order of RGS 4 > 19 = 16 > 8 7. CCG-63808 inhibited the GTPase accelerating protein activity of RGS4.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CCG-63808, CCG63808, CCG 63808, inhibit, Inhibitor, RGS4, RGS Protein, RGS19, Regulator of G-protein Signaling, Regulators of G-protein Signaling

Compound Identifiers

PubChem CID

5948316