CCG-222740

SKU: orb1299529

Description

CCG-222740 is a potent and selective small molecule inhibitor targeting the Rho/MRTF signaling pathway. It is utilized in research to investigate fibrotic diseases, cancer metastasis, and vascular remodeling in both cellular and animal models.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1922098-69-8
• MW: 444.86
• Purity: 98.79% (May vary between batches)
• Formula: C₂₃H₁₉ClF₂N₂O₃
• SMILES: FC1(F)CC(CN(C1)C(=O)c1cccc(c1)-c1ccco1)C(=O)Nc1ccc(Cl)cc1
• Target: Rho,ROCK,Ras
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.99 mM);DMSO:125 mg/mL (280.99 mM)

Bioactivity

• In Vitro:
  CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

muscle, myocardin-related, inhibit, MRTF, Inhibitor, metastasis, orally, melanoma, fibrosis, expression, factor, CCG 222740, actin, alpha-smooth, CCG222740, CCG-222740, Rho, Rho-associated kinase, Rho-associated protein kinase, Rho-kinase, ROK, ROCK, protein, Ras, transcription

Compound Identifiers

PubChem CID

121317937