CCF642

SKU: orb1300453

Description

CCF642 (AC1LYELL) is a novel small molecule inhibitor of protein disulfide isomerase (PDI) with demonstrated anti-myeloma activity. Research applications include investigating PDI's role in hematological cancers, utilizing it for in vitro cell viability assays, and evaluating its efficacy in in vivo xenograft models of multiple myeloma.

Research Area

Cell Biology

Key Properties

• CAS Number: 346640-08-2
• MW: 378.45
• Purity: 99.57% (May vary between batches)
• Formula: C₁₅H₁₀N₂O₄S₃
• SMILES: COc1ccc(cc1)N1C(=S)S\C(=C\c2ccc(s2)[N+]([O-])=O)C1=O
• Target: Others,Apoptosis
• Solubility: DMSO:11.11 mg/mL (29.36 mM)

Bioactivity

• Target IC50:
  PDI:2.9 μmol/L
• In Vivo:
  CCF642 displays potent efficacy in an aggressive syngeneic mouse model of multiple myeloma and prolongs the lifespan of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma, an effect comparable to the first-line multiple myeloma therapeutic bortezomib.
• In Vitro:
  In vitro, CCF642 inhibits PDI reductase activity about 100-fold more potently than the structurally distinct established inhibitors PACMA 31 and LOC14. Computational modeling suggests a novel covalent binding mode in active-site CGHCK motifs. CCF642 causes acute ER stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

myeloma, multiple, isomerases, Inhibitor, inhibit, PDI, disulfide, CCF 642, CCF642, CCF-642, AC1LYELL, apoptosis, anti-multiple, calcium, protein, stress, release

Compound Identifiers

PubChem CID

1820764