CC214-1

SKU: orb1962231

Description

CC214-1 is a potent and selective mTOR kinase inhibitor used as an in vitro research tool. It suppresses protein synthesis and triggers autophagy, making it valuable for studying mTOR biology in cancer research, including investigations into multiple myeloma.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1021920-32-0
• MW: 391.43
• Purity: 97.87% (May vary between batches)
• Formula: C₂₀H₂₁N₇O₂
• SMILES: O=C1NC2=NC=C(N=C2N1CCC3CCOCC3)C=4C=CC(=CC4)C5=NN=CN5
• Target: Autophagy,mTOR

Bioactivity

• Target IC50:
  mTOR:0.002 μM
• In Vitro:
  CC214-1 (0,0.1,1,2,5,10 μM, 8h; 2μM, 24h)Inhibited mTORC1 signaling in all glioblastoma cell lines tested, potently suppressing rapamycin-resistant 4E-BP1 and mTORC2 signaling.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mTOR, CC214 1, CC2141, CC214-1, Autophagy

Compound Identifiers

PubChem CID

66699750