CC-90001

SKU: orb1297947

Description

CC-90001

Research Area

Signal Transduction

Key Properties

• CAS Number: 1403859-14-2
• MW: 321.42
• Purity: 99.96% (May vary between batches)
• Formula: C₁₆H₂₇N₅O₂
• SMILES: C[C@@H]1CC[C@H](C[C@H]1O)Nc1nc(NC(C)(C)C)ncc1C(N)=O
• Target: JNK
• Solubility: DMSO:125 mg/mL (388.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.44 mM)

Bioactivity

• In Vivo:
  CC-90001 effectively mitigates lung fibrosis by significantly decreasing lung collagen metrics and lowering disease-induced α-SMA increases to nearly baseline levels in a house dust mite-induced lung fibrosis model. Moreover, when administered at a dosage of 3 mg/kg b.i.d., it hampers fibrosis development, evidenced by a notable reduction of 48% in collagen and 53% in α-smooth muscle actin (α-SMA) within a steatohepatitis model.
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• In Vitro:
  CC-90001 is 12.9-fold more potent for JNK1 inhibition over JNK2 in knockout fibroblasts. CC-90001 blocks LPS-induced c-jun phosphorylation (EC50 = 480 nM).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CC 90001, CC90001, CC-90001, c-Jun, fibrosis, hJNK1, Inhibitor, idiopathic, N-terminal, JNK1, JNK, inhibit, kinase, IPF, pulmonary

Compound Identifiers

PubChem CID

71237511