CC-11

SKU: orb3174093

Description

CC-11 is an orally bioavailable small molecule drug conjugate (SMDC) that links a PI3K/mTOR inhibitor to an extracellular heat shock protein 90 (EHSP90) targeting ligand via a cleavable linker. It exhibits strong binding activity to HSP90 (IC50 = 15 nM) and inhibits PI3Kα kinase activity (IC50 = 0.54 nM). CC-11 shows antiproliferative effects against colon cancer cells and demonstrates significant efficacy in the HCT-116 xenograft model. It is applicable in colon cancer research.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 3079942-94-9
• MW: 1077.13
• Formula: C₅₂H₅₄F₂N₁₂O₁₀S
• SMILES: O=C(OC1CN(CCCN2N=NC(=C2)C3=CN=C4C=CC(=NN43)C=5C=NC(OC)=C(C5)NS(=O)(=O)C6=CC=C(F)C=C6F)CCC1)CNC(=O)CCC(=O)NC7=CC=C8C(=C7)CCN8C(=O)C=9C=C(C(O)=CC9O)C(C)C
• Target: HSP,PI3K,Akt,mTOR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HSP,PI3K,Akt,mTOR