Cbz-B3A

SKU: orb1707491

Description

Cbz-B3A is a potent and selective mTORC1 inhibitor that suppresses 4EBP1 phosphorylation, leading to a significant (68%) inhibition of protein translation. This compound is a valuable research tool for studying mTOR signaling in cancer biology, autophagy, and cellular metabolism, with applications in both in vitro and in vivo experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1884710-81-9
• MW: 706.87
• Purity: 98.63% (May vary between batches)
• Formula: C₃₅H₅₈N₆O₉
• SMILES: C(=NCCC[C@@H](C(NCCCCCCNC(OCC1=CC=CC=C1)=O)=O)NC(OC(C)(C)C)=O)(NC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O
• Target: mTOR
• Solubility: DMSO:10 mg/mL (14.15 mM)

Bioactivity

• In Vitro:
  Cbz-B3A (10 μM) inhibits the phosphorylation of 4EBP1 and p70S6k Thr-389 .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mTORC1, mTORC1 signaling, CbzB3A, Cbz-B3A, Cbz-B-3A, Cbz B3A

Compound Identifiers

PubChem CID

124203916