CBL0137

SKU: orb1303131

Description

CBL0137 is a metabolically stable curaxin that potently activates p53 and inhibits NF-κB by inactivating the FACT complex. It demonstrates broad in vivo anticancer activity, eradicates resistant cancer stem cells, and synergizes with gemcitabine in preclinical pancreatic cancer models.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 1197996-80-7
• MW: 336.43
• Purity: 99.68%
• Formula: C₂₁H₂₄N₂O₂
• SMILES: C(CNC(C)C)N1C=2C(C=3C1=CC=C(C(C)=O)C3)=CC(C(C)=O)=CC2
• Target: NF-κB,Histone Acetyltransferase,p53,MDM-2/p53
• Solubility: H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.94 mM);DMSO:25 mg/mL (74.31 mM)

Bioactivity

• Target IC50:
  NF-κB:0.47 μM (EC50)|p53:0.37 μM (EC50)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NFkB, NF-kB, NFκB, NF-κB, p53, CBLC 137, CBL0137, CBL-0137, CBLC137, CBLC-137, CBL 0137, Curaxin 137

Compound Identifiers

PubChem CID

44519124