Cbl-b-IN-8

SKU: orb2277582

Description

Cbl-b-IN-8 (Compound 293) is a potent dual inhibitor of the E3 ubiquitin ligases Cbl-b and c-Cbl, with IC50 values of 5.5 nM and 7.8 nM, respectively. This small molecule is a valuable research tool for investigating immune regulation and oncogenic signaling pathways in both cellular and animal models.

Research Area

Cancer Biology, Protein Biochemistry

Key Properties

• CAS Number: 2815223-33-5
• MW: 667.76
• Formula: C₃₅H₄₄F₃N₇O₃
• SMILES: C(C1(COC1)C=2C=C(N=C(OC3CCCC3)C2)N4CC=5C(C4=O)=CC(CN6[C@@H]([C@H](C)C)CN(C)CC6)=CC5C(F)(F)F)C=7N(C)C=NN7
• Target: E1/E2/E3 Enzyme

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

164869245