Cbl-b-IN-6

SKU: orb2277584

Description

Cbl-b-IN-6 (Compound 246) is a potent dual inhibitor of the E3 ubiquitin ligases Cbl-b and c-Cbl, with IC50 values of 6.7 nM and 5.2 nM, respectively. This small molecule is a valuable research tool for investigating immune cell signaling and has been utilized in both in vitro and in vivo studies exploring T-cell activation and potential immunotherapeutic applications.

Research Area

Cancer Biology, Protein Biochemistry

Key Properties

• CAS Number: 2815221-33-9
• MW: 573.6
• Formula: C₃₀H₃₂F₅N₅O
• SMILES: C(C1(CC(F)(F)C1)C2=CC(=CC=C2)N3CC=4C(C3=O)=CC([C@@H](NC5(C)CCC5)C)=CC4C(F)(F)F)C=6N(C)C=NN6
• Target: E1/E2/E3 Enzyme

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

164868941