Cbl-b-IN-3

SKU: orb1686246

Description

Cbl-b-IN-3 is a highly potent and selective small molecule inhibitor of the E3 ubiquitin ligase Cbl-b, exhibiting an IC50 of less than 1 nM. This compound is a valuable research tool for investigating Cbl-b's role in modulating T-cell activation and immune tolerance in both cellular and animal models of autoimmunity and cancer immunotherapy.

Research Area

Cancer Biology, Protein Biochemistry

Key Properties

• CAS Number: 2573775-59-2
• MW: 537.62
• Purity: 99.00% (May vary between batches)
• Formula: C₃₀H₃₄F₃N₅O
• SMILES: CN1C([C@]2(C[C@@H](C)C2)C3=CC(=CC=C3)N4CC=5C(C4=O)=CC(CN6C[C@@H](C)CCC6)=CC5C(F)(F)F)=NN=C1
• Target: E1/E2/E3 Enzyme
• Solubility: DMSO:11.15 mg/mL (20.74 mM)

Bioactivity

• In Vitro:
  METHODS: The ability to inhibit Cbl-b activity was determined by monitoring the interaction of Cbl-b with a fluorophore-labeled probe in the presence of Cbl-b-IN-3. RESULTS The IC50 value of Cbl-b-IN-3 inhibiting Cbl-b is less than 1 nM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E2Enzyme, E3 Enzyme, E3Enzyme, Cbl, E1 Enzyme, E1/E2/E3 Enzyme, E1Enzyme, E2 Enzyme

Compound Identifiers

PubChem CID

155449671