Cbl-b-IN-29

SKU: orb3173977

Description

Cbl-b-IN-29 is an orally active inhibitor of CBL-B. It effectively binds to the active site of CBL-B, thereby inhibiting the function of the immune E3 ubiquitin ligase. Cbl-b-IN-29 can induce the release of IL-2 from Jurkat cells with an EC50 of 159 nM. This compound exhibits significant antitumor efficacy in vivo, showing good tolerance with no adverse effects observed. Cbl-b-IN-29 is applicable in cancer immunotherapy and related studies involving colon cancer and tumor immunotherapy combinations.

Research Area

Immunology & Inflammation, Protein Biochemistry

Key Properties

• CAS Number: 3070411-10-5
• MW: 499.63
• Formula: C₃₀H₃₄FN₅O
• SMILES: CN1C([C@@]2(C[C@H](C)C2)C3=CC(=CC=C3)C4=CC=5C(NC4=O)=C([C@H](NC6CCCC6)C)C=CC5F)=NN=C1
• Target: E1/E2/E3 Enzyme,Interleukin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

E1/E2/E3 Enzyme,Interleukin