Cbl-b-IN-13

SKU: orb2277577

Description

Cbl-b-IN-13 is a potent small molecule inhibitor of the E3 ubiquitin ligase Cbl-b, demonstrating an IC50 below 100 nM. Its inhibition of Cbl-b leads to T-cell activation, making it a valuable research tool for studying immune-oncology and T-cell function in both cellular and animal models.

Research Area

Cancer Biology, Protein Biochemistry

Key Properties

• CAS Number: 2368841-85-2
• MW: 537.58
• Formula: C₂₉H₃₀F₃N₅O₂
• SMILES: O=C1C2=CC(=CC(=C2CN1C3=CC=CC(=C3)C4(COC4)CC5=NN=CN5C)C(F)(F)F)CN6CCC7(C6)CC7
• Target: E1/E2/E3 Enzyme

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

139350899