Cbl-b-IN-12

SKU: orb2277578

Description

Cbl-b-IN-12 is a potent small molecule inhibitor of the E3 ubiquitin ligase CBL-B, exhibiting an IC50 value below 100 nM. This compound is a valuable research tool for investigating CBL-B's role in immune cell signaling and has been utilized in both cellular and animal studies to explore T-cell activation and potential immunotherapeutic applications.

Research Area

Cancer Biology, Protein Biochemistry

Key Properties

• CAS Number: 2851871-29-7
• MW: 538.56
• Formula: C₂₈H₂₉F₃N₆O₂
• SMILES: C(C1(COC1)C2=CC(=CC=C2)N3C=C4N(C3=O)C=C(CN5CC6(CC5)CC6)C=C4C(F)(F)F)C=7N(C)C=NN7
• Target: E1/E2/E3 Enzyme

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166079710