CB30865

SKU: orb1707494

Description

CB30865 (ZM 242421) is a potent and selective Nampt inhibitor, exhibiting antitumor properties. It is used in cancer metabolism research to study NAD+ depletion, demonstrating efficacy in both in vitro cell culture models and in vivo xenograft studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 206275-15-2
• MW: 516.39
• Purity: 99.04% (May vary between batches)
• Formula: C₂₆H₂₂BrN₅O₂
• SMILES: O=C1N=C(NC2=CC(Br)=C(C=C12)CN(C3=CC=C(C=C3)C(=O)NCC=4C=NC=CC4)CC#C)C
• Target: NAMPT
• Solubility: H2O:< 0.1 mg/mL (insoluble);DMSO:30 mg/mL (58.1 mM)

Bioactivity

• In Vitro:
  CB30865 showed dramatically increased W1L2 cytotoxicity (EC50=2.8 nM) that was not rescued by precursors or end-products of folate metabolism. CB30865 represents a class of compounds with unique biochemical characteristics such as a delayed, non-phase specific, cell-cycle arrest. CB30865 represents a class of compounds with unique biochemical characteristics such as a delayed, non-phase specific, cell-cycle arrest.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CB30865, CB-30865, CB 30865, Nampt, ZM 242421, ZM242421, ZM-242421

Compound Identifiers

PubChem CID

135528987