CB2R PAM

SKU: orb1693188

Description

CB2R PAM is an orally bioavailable positive allosteric modulator of the cannabinoid CB2 receptor. It potentiates agonist-stimulated G-protein activity in vitro and demonstrates efficacy in a murine neuropathic pain model, supporting research in analgesia and neuroinflammation.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2244579-87-9
• MW: 435.33
• Purity: 99.09% (May vary between batches)
• Formula: C₂₁H₂₄BrFN₂O₂
• SMILES: N(C(=O)C1CCCCCC1)C=2C(=O)N(CC3=CC=C(F)C=C3)C=C(Br)C2C
• Target: Cannabinoid Receptor
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (4.59 mM);DMSO:45 mg/mL (103.37 mM)

Bioactivity

• In Vivo:
  CB2R PAM (1-20 mg/kg; p.o.) exhibits antinociceptive activity.
• In Vitro:
  CB2R Positive Allosteric Modulator (PAM) at a concentration of 100 nM notably enhances the capability of CP55940 and 2-AG, without affecting AEA, in promoting [35S]GTPγS binding to CB2 receptors.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CB2R, CB2R PAM, CannabinoidReceptor, Cannabinoid Receptor, Ec2la

Compound Identifiers

PubChem CID

137553165