CAY10650

SKU: orb1296200

Description

CAY10650

Research Area

Metabolism Research

Key Properties

• CAS Number: 1233706-88-1
• MW: 471.5
• Purity: 95.56% (May vary between batches)
• Formula: C₂₈H₂₅NO₆
• SMILES: CC(C)C(=O)c1cn(CC(=O)COc2ccc(Oc3ccccc3)cc2)c2ccc(cc12)C(O)=O
• Target: Phospholipase
• Solubility: DMSO:40 mg/mL (84.84 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.24 mM)

Bioactivity

• Target IC50:
  CPLA2α:12 nM
• In Vivo:
  CAY10650 demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis. Chinese hamsters (n = 6/group) were infected with parasite-laden contact lenses and treated with cPLA2α inhibitors (AACOCF3 and CAY10650) 50 μg/5 μl was injected with topical eye-drop under the contact lens of an infected cornea three times a day for 6 days and topically on days 7–14 postinfection. Animals were anesthetized and sacrificed 15 days after the application of cPLA2α inhibitors. Treatment with the AACOCF3 and CAY10650 had a profound effect on the severity and chronicity of keratitis. In addition, hamsters treated with AACOCF3 had significantly less severe keratitis as compared with the CAY10650 group.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

corneal epithelial cells, CAY10650, CAY-10650, CAY 10650, cPLA2α, acanthamoeba, mannose-induced protein, Inhibitor, neutrophils, keratitis, lipid droplets, inhibit, PGE2, Phospholipase

Compound Identifiers

PubChem CID

45102612