CAY10603

SKU: orb1306854

Description

CAY10603 (BML-281) is a highly selective HDAC6 inhibitor used in biochemical and cellular research. It is a valuable tool compound for investigating HDAC6's role in oncology, neurology, and immunology, with applications in both in vitro and in vivo experimental models.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1045792-66-2
• MW: 446.5
• Purity: 98.10% (May vary between batches)
• Formula: C₂₂H₃₀N₄O₆
• SMILES: C(NCCCCCCC(NO)=O)(=O)C=1C=C(ON1)C2=CC=C(NC(OC(C)(C)C)=O)C=C2
• Target: HDAC
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:82 mg/mL (183.65 mM);Ethanol:5 mg/mL (11.2 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.39 mM)

Bioactivity

• Target IC50:
  HDAC1:271 nM|HDAC2:252 nM|HDAC8:6851 nM|HDAC6:2 pM|HDAC10:90.7 nM|HDAC3:0.42 nM
• In Vivo:
  CAY10603 exhibits effective anti-proliferative activity against pancreatic cancer cell lines by inhibiting HDAC6, with an IC50 of less than 1 μM.
• Cell Research:
  The pancreatic cancer cell lines BxPc-3, HupT3, Mia Paca-2, Panc 04.03, and SU 86.86 are grown in medium (DMEM or RPMI) containing 10% fetal calf serum and l-glutamine. Pancreatic cancer cells are plated out in duplicate into 6 wells of a 96-well microtiter plate. Four hours post plating, individual wells are treated with diluent (DMSO) or varying concentrations of SAHA or the indicated HDACIs from a concentration of 1 nM to 50 mM. Cytotoxicity is measured at time "0", and 72 h post treatment using the colorimetric MTT assay according to the manufacturer's suggestions. The IC50 values are calculated using XLfit.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Histone deacetylases, Inhibitor, HDAC1, HDAC6, HDAC6 Inhibitor, HDAC, CAY 10603, CAY10603, CAY-10603, BML281, BML-281, BML 281

Compound Identifiers

PubChem CID

24951314