CAY10583

SKU: orb1700911

Description

CAY10583 is a selective BLT2 agonist that upregulates TGF-β1 and bFGF. This activity enhances keratinocyte migration and fibroblast proliferation in vitro and accelerates wound closure in diabetic mouse models, supporting research in dermatology and diabetic wound healing.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 862891-27-8
• MW: 387.47
• Purity: >99.99% (May vary between batches)
• Formula: C₂₅H₂₅NO₃
• SMILES: O=C(O)C=1C=CC=CC1C=2C=CC(=CC2)CN(C=3C=CC=CC3)C(=O)CCCC
• Target: FGFR,Leukotriene Receptor,TGF-beta/Smad

Bioactivity

• In Vivo:
  In high-fat diet–induced obese mice, CAY10583 was administered intraperitoneally at 10 mg/kg once daily for 4 weeks. The treatment significantly reduced body weight gain, serum total cholesterol, and triglyceride levels, and increased phosphorylation of AMPK and ACC in liver tissues, indicating lipid metabolism improvement and anti-obesity effects.
• In Vitro:
  CAY10583 significantly activated AMPK in human hepatocellular carcinoma HepG2 cells. Treatment with 50 μM CAY10583 for 1 hour increased phosphorylation levels of AMPK and its downstream target ACC, indicating metabolic regulatory activity as an AMPK activator. CAY10583 also suppressed expression of lipogenesis-related proteins such as FAS and SREBP-1c.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CAY10583, CAY-10583, CAY 10583

Compound Identifiers

PubChem CID

51529932