CAY10566

SKU: orb1308491

Description

CAY10566 is a potent, orally bioavailable, and selective SCD1 inhibitor, demonstrating excellent cellular activity in HepG2 cells and low nanomolar IC₅₀ values in enzymatic assays. This inhibitor is a valuable research tool for studying lipid metabolism in models of metabolic disease, obesity, and cancer in both in vitro and in vivo settings.

Research Area

Metabolism Research

Key Properties

• CAS Number: 944808-88-2
• MW: 389.81
• Purity: 99.54% (May vary between batches)
• Formula: C₁₈H₁₇ClFN₅O₂
• SMILES: Cc1nnc(o1)-c1ccc(nn1)N1CCC(CC1)Oc1cc(F)ccc1Cl
• Target: Dehydrogenase|||Stearoyl-CoA Desaturase (SCD)
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.13 mM);DMSO:26.84 mg/mL (68.85 mM)

Bioactivity

• Target IC50:
  SCD1 (mouse):4.5 nM (IC50)|SCD1 (human):26 nM (IC50)
• In Vivo:
  Upon the formation of detectable tumors, mice receive either a placebo or the SCD1 inhibitor CAY10566 (2.5 mg/kg orally twice daily). SCD1 inhibition demonstrates a more pronounced effect on Akt-driven tumors compared to Ras-driven tumors. Specifically, the average tumor volume on days 13 or 14 after treatment, compared to control tumors, was 0.5±0.04 for Akt-driven tumors and 0.67±0.05 for Ras-driven tumors (P=0.01 for Ras-Akt comparison, according to a two-tailed t-test) .
  Read more...
• In Vitro:
  CAY10566 (0.0001-10 μM; 24 hours) concentration-dependently decreases Swiss 3T3 cell proliferation .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CAY10566, CAY-10566, CAY 10566, Inhibitor, inhibit, SCD1, SCD, Stearoyl-CoA Desaturase, Stearoyl-CoA Desaturase (SCD), StearoylCoA Desaturase (SCD), StearoylCoADesaturase, StearoylCoADesaturase(SCD)

Compound Identifiers

PubChem CID

16732433