Caulophyllogenin

SKU: orb1297430

Description

Caulophyllogenin, a natural partial PPARγ agonist (EC50 = 12.6 µM) from Kalopanax pictus, suppresses pro-inflammatory cytokine secretion. This activity supports its research utility in studying metabolic and inflammatory conditions, including type-2 diabetes, obesity, and metabolic syndrome, in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 52936-64-8
• MW: 488.7
• Purity: 98.56% (May vary between batches)
• Formula: C₃₀H₄₈O₅
• SMILES: C(O)(=O)[C@]12[C@](C=3[C@@](C)(C[C@H]1O)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)([C@@](CO)(C)[C@@H](O)CC5)[H])[H])(CC(C)(C)CC2)[H]
• Target: IL Receptor|||PPAR|||Immunology/Inflammation related|||TNF
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:100 mg/mL (204.62 mM)

Bioactivity

• Target IC50:
  PPARγ:12.6 μM (EC50)
• In Vitro:
  Caulophyllogenin inhibits IL-12 p40, IL-6, and TNF-α with IC50s ranging from 3.3 to 20.0 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PPARγ, Segetalic acid, TNF-α, IL Receptor, IL-12, ILReceptor, IL-6, Immunology related, Immunologyrelated, Inflammationrelated, inflammation, Inflammation related, Caulophyllogenin

Compound Identifiers

PubChem CID

104361