Caulilexin C

SKU: orb1297431

Description

Caulilexin C is a bioactive small molecule that inhibits both human ACAT1 and ACAT2 enzymes at a concentration of 100 µg/mL. This dual inhibitor is a valuable research tool for studying cholesterol esterification and lipid metabolism in cellular (in vitro) models relevant to atherosclerosis and metabolic disease.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 30536-48-2
• MW: 186.21
• Purity: 99.62% (May vary between batches)
• Formula: C₁₁H₁₀N₂O
• SMILES: COn1cc(CC#N)c2ccccc12
• Target: Antifungal
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.74 mM);DMSO:50 mg/mL (268.51 mM)

Bioactivity

• In Vitro:
  Toward this end, the metabolism of indolyl glucosinolates, their corresponding desulfo-derivatives, and derived metabolites, by three fungal species pathogenic on crucifers was investigated. While glucobrassicin, 1-methoxyglucobrassicin, 4-methoxyglucobrassicin were not metabolized by the pathogenic fungi Alternaria brassicicola, Rhizoctonia solani and Sclerotinia sclerotiorum, the corresponding desulfo-derivatives were metabolized to indolyl-3-acetonitrile, Caulilexin C (1-methoxyindolyl-3-acetonitrile) and arvelexin (4-methoxyindolyl-3-acetonitrile) by R. solani and S. sclerotiorum, but not by A. brassicicola. That is, desulfo-glucosinolates were metabolized by two non-host-selective pathogens, but not by a host-selective. Indolyl-3-acetonitrile, Caulilexin C and arvelexin were metabolized to the corresponding indole-3-carboxylic acids. Indolyl-3-acetonitriles displayed higher inhibitory activity than indole desulfo-glucosinolates. Indolyl-3-methanol displayed antifungal activity and was metabolized by A. brassicicola and R. solani to the less antifungal compounds indole-3-carboxaldehyde and indole-3-carboxylic acid.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight,keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Caulilexin C, antifungal, Fungal, hACAT2, hACATI, Inhibitor, inhibit, phytoalexin

Compound Identifiers

PubChem CID

11954881