Cathelicidin-2 (128-153) (chicken) TFA

SKU: orb1980103

Description

Cathelicidin-2 (CATH-2) (128-153) is a synthetic antimicrobial peptide derived from amino acids 128-153 of chicken CATH-2, demonstrating activity against pathogens such as E. coli, S. aureus, S. enteritidis, and B. globigii in a dose-dependent manner. At a concentration of 40 µM, it induces hemolysis in chicken erythrocytes without exhibiting cytotoxicity towards human peripheral blood mononuclear cells (PBMCs). Additionally, it stimulates the production of the chemokine CCL2 and suppresses LPS-induced secretion of TNF-α, IL-6, IL-8, and IL-10 in human PBMCs.

Key Properties

• MW: 3206.90
• Formula: C₁₄₇H₂₄₅N₅₁O₃₀.XCF₃COOH
• SMILES: [H]NCCCC[C@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC(CNC([C@@H](NC([C@H](CCCNC(N)=N)N[H])=O)CC1=CC=CC=C1)=O)=O)=O)CC2=CC=CC=C2)=O)CC(C)C)=O)=O)C(N[C@@](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N3CCC[C@H]3C(N[C@@H](CCCCN[H])C(N[C@@H](C(C)C)C(N[C@@]([H])([C@@H](C)O)C(N[C@@](C(N[C@@]([H])([C@@H](C)O)C(N[C@@](C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)=O)C)=O)=O)=O)=O)([H])[C@H](CC)C)=O)=O)([H])[C@H](CC)C)=O)=O)=O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)([H])[C@H](CC)C)=O.OC(C(F)(F)F)=O

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only