β-catenin inhibitory peptoid

SKU: orb3142480

Description

β-catenin inhibitory peptoid (compound 13) disrupts the interaction between β-catenin and TCF with an IC50 of 5.44 µM. It inhibits Wnt signaling in prostate cancer cell lines (IC50 = 0.105 µM) and androgen receptor (AR) signaling (IC50 = 1.02 µM). This compound significantly reduces cell proliferation in prostate cancer cell lines.

Research Area

Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• Target: Androgen Receptor,Wnt/beta-catenin
• CAS Number: 2579070-02-1
• MW: 1057.24
• Formula: C₅₉H₇₂N₆O₁₂
• SMILES: O=C1N(CC(=O)N(CCCOC(C)C)CC(=O)N([C@@H](C)C2=CC=C(OC)C=C2)CC(=O)N([C@@H](C)C3=CC=C(OC)C=C3)CC(=O)N[C@H](C)C(=O)N(CCC4=C(OC5=CC=CC=C5)C=CC=C4)C1)C6=CC(OC)=CC(OC)=C6

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Androgen Receptor,Wnt/beta-catenin