Castanospermine

SKU: orb1296063

Description

Castanospermine is a natural indolizidine alkaloid that acts as a potent inhibitor of α- and β-glucosidases, with notable activity against glucosidase I. It is widely used in biochemical research to study glycoprotein processing, viral entry mechanisms, and metabolic disorders in both cellular and animal models.

Research Area

Cardiovascular Research

Key Properties

• CAS Number: 79831-76-8
• MW: 189.2
• Purity: >98%
• Formula: C₈H₁₅NO₄
• SMILES: OC1CCN2CC(O)C(O)C(O)C12
• Target: Glycosylation
• Solubility: Soluble in Water (up to 25 mg/ml)

Bioactivity

• In Vivo:
  Experiments in vivo with castanospermine, an inhibitor of the glucosidases that convert protein N-linked high mannose carbohydrates to complex oligosaccharides, resulted in significant inhibition of tumor growth in nude mice .
• In Vitro:
  Castanospermine is a potent and specific inhibitor of mammalian and plant α-and β-D-glucosidases in vitro .

Storage & Handling

• Storage: 4°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Castanospermine, (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine, 1,6,7,8-Tetrahydroxyoctahydroindolizine, inhibit, Inhibitor, Glucosidase, α-glucosidase, β-glucosidase

Compound Identifiers

PubChem CID

2592