β-Casomorphin, bovine

SKU: orb2655250

Description

β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay.(In Vitro):β-Casomorphin, bovine (0.1 μM; 30 minutes-24 hours) stimulates the secretion of mucin in DHE Cells after 8 h of treatment. β-Casomorphin, bovine (0.1 μM; 24 hours) induces an increase in rMuc2 and rMuc3 mRNA levels. β-Casomorphin, bovine do not modify the expression of rMuc1, rMuc4, and rMuc5AC. β-Casomorphin, bovine (0.1 μM; 24 hours) stimulates MUC5AC expression and mucin Secretion in HT29-MTX Cells (human).(In Vivo):β-Casomorphin, bovine (7.5×10 6 mol/day/kg ; i.g.; for 30 days) increases plasma insulin and decreased plasma glucagon of diabetic rats. β-Casomorphin, bovine (7.5×10 6 mol/day/kg ; i.g.; for 30 days) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats. β-Casomorphin, bovine (7.5×10 6 mol/day/kg ; i.g.; for 30 days) reduces MDA (significantly) and H2O2 (non-significantly) level in the kidney compared to the diabetic rats. β-Casomorphin, bovine (7.5×10 6 mol/day/kg ; i.g.; for 30 days) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells.

Key Properties

• CAS Number: 72122-62-4
• MW: 789.92
• Purity: >98% (HPLC)
• Formula: C₄₁H₅₅N₇O₉
• Target: Opioid Receptor
• Solubility: In Vitro: DMSO : 100 mg/mL (126.60 mM)

Bioactivity

• In Vivo:
  β-Casomorphin, bovine (7.5×10 6 mol/day/kg; i. g. ; for 30 days) increases plasma insulin and decreased plasma glucagon of diabetic rats. β-Casomorphin, bovine (7.5×10 6 mol/day/kg; i. g. ; for 30 days) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats. β-Casomorphin, bovine (7.5×10 6 mol/day/kg; i. g. ; for 30 days) reduces MDA (significantly) and H2O2 (non-significantly) level in the kidney compared to the diabetic rats. β-Casomorphin, bovine (7.5×10 6 mol/day/kg; i. g. ; for 30 days) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells. Animal model: Male Sprague-Dawley (SD) rats (200 g±10 g). Dosage: 7.5×10 6 mol/day/kg. Administration: Oral gavage; for 30 days. Result: Increased plasma insulin and decreased plasma glucagon of diabetic rats.
• In Vitro:
  β-Casomorphin, bovine (0.1 μM; 30 minutes-24 hours) stimulates the secretion of mucin in DHE Cells after 8 h of treatment. β-Casomorphin, bovine (0.1 μM; 24 hours) induces an increase in rMuc2 and rMuc3 mRNA levels. β-Casomorphin, bovine do not modify the expression of rMuc1, rMuc4, and rMuc5AC. β-Casomorphin, bovine (0.1 μM; 24 hours) stimulates MUC5AC expression and mucin Secretion in HT29-MTX Cells (human).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

β-Casomorphin-7 (bovine); Bovine β-casomorphin-7

Quick Database Links

Gene Symbol

Opioid Receptor