CASIN

SKU: orb1303494

Description

CASIN (Pirl1-related Compound 2) is a cell-permeable, selective small-molecule inhibitor of the Rho GTPase Cdc42 with an IC50 of 2 µM. It is widely used in cell biology research to study cytoskeletal dynamics, cell polarity, and migration in both cellular and animal models.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 425399-05-9
• MW: 306.4
• Purity: >99.99% (May vary between batches)
• Formula: C₂₀H₂₂N₂O
• SMILES: OCCNC1CCCc2c1[nH]c1ccc(cc21)-c1ccccc1
• Target: Apoptosis,Ras,STAT,CDK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.53 mM);DMSO:55 mg/mL (179.5 mM)

Bioactivity

• Target IC50:
  GTPase CDC42:2 μM
• In Vivo:
  CASIN can reverse the aging-related and polarity phenotype of aged HSCs to that of young HSCs.
• In Vitro:
  CASIN (5 uM) could reduce the elevated level of active Cdc42 in aged primitive hematopoietic cells to the level in young cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, CASIN, bortezomib, drug resistance, Inhibitor, GTPase Cdc42, multiple myeloma, inhibit, STAT3, Pirl1-related Compound 2, Ras

Compound Identifiers

PubChem CID

2882155