Cas9-IN-2

SKU: orb1686914

Description

Cas9-IN-2 is a potent small-molecule inhibitor of the Cas9 nuclease, exhibiting an IC50 of 246 µM by binding to apo-Cas9 and preventing gRNA complex formation. This inhibitor serves as a valuable chemical tool for the precise temporal control of CRISPR-Cas9 activity in both in vitro biochemical assays and cellular research applications.

Research Area

Molecular Biology

Key Properties

• CAS Number: 1030133-34-6
• MW: 477.6
• Formula: C₂₁H₂₇N₅O₄S₂
• SMILES: CN1C(C=2SC(C(=O)N3CCC(C)CC3)=C(C)N2)=CC(S(NC4=NOC(C)=C4)(=O)=O)=C1C
• Target: Others,CRISPR/Cas9

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

50829168